Lipofuscin Hypothesis of Alzheimer’s Disease
نویسندگان
چکیده
منابع مشابه
Lipofuscin Hypothesis of Alzheimer's Disease
The primary culprit responsible for Alzheimer's disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the brain in the course of sporadic AD. The aim...
متن کاملMagnesium and Alzheimers Disease: The Cholinergic Hypothesis
The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
متن کاملAlzheimers Disease: A Novel Hypothesis for the Development and the Subsequent Role of Beta Amyloid
Spirochetes, biofilms, and innate immune system activity have all been recently found in the brains of Alzheimer’s disease patients. The mechanism and actions of those factors in producing the disease were discussed in those studies. However, neither the production nor the role of beta amyloid was included in the discussion of those studies. In this commentary, we hypothesize how the developmen...
متن کاملA Comprehensive Analysis on Different Types of Hypothesis, Diagnosis and Treatment of Alzheimers Disease
Alzheimer’s disease was first identified more than 100 years ago, but 70 years passed before it was recognized as the most common cause of dementia and treated as killing instrument. Alzheimer's disease generally emerges in old age beyond 65 years and mostly in 85 years symbolising deterioration of cognitive functions such as remembering, reasoning, and planning and the like. Many scientists be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Dementia and Geriatric Cognitive Disorders Extra
سال: 2011
ISSN: 1664-5464
DOI: 10.1159/000329544